AGC provides CDMO services with organic synthesis process development capabilities cultivated through the pharmaceuticals and agrochemicals CDMO business, raw material procurement capabilities with the original global network, and manufacturing capabilities to achieve stable supply at low cost while continuing to pursue operational excellence.

Service overview

Using precision synthesis technology cultivated through the pharmaceuticals and agrochemicals CDMO businesses, AGC manufactures organic materials on contract in various needs of manufacturing volumes and synthesis processes. We propose continued cost reduction through efficient process development and the solutions for the challenges in manufacturing process with alternative synthetic routes, etc. We achieve a stable supply of products through multiple production facilities at multiple locations, stable procurement of raw materials through our own supply chain scheme, and flexible manufacturing planning and management.

Our Uniqueness

  • Stable production through risk diversification
    Stable supply of products is achieved through the establishment of multiple production facilities at multiple locations, stable procurement of raw materials through our own supply chain scheme, etc.
  • One-stop solution from process development to manufacturing
    Using precision organic synthesis technology and quality assurance systems cultivated through the pharmaceuticals and agrochemicals CDMO business, and reaction equipment of various sizes from 100L to 15m3, we fully support our customers in procuring high-quality, low-cost organic materials from process development to commercial production.
  • Global standard high level and stable quality assurance system
    AGC has obtained EcoVadis Gold rating (top 5%).
    Under the integrated quality management system with our pharmaceutical quality assurance system, provides the high quality and stable quality service.

Manufacturing bases / equipment

<AGC Wakasa Chemicals: Obama Plant / pharmaceuticals Plant > (Obama City, Fukui Prefecture)

AGC Wakasa Chemicals
Equipment Material Volume Numbers Design Temp. (°C)
Reactors Stainless (SUS), Glass Lining (GL),
PFA Lining		 100～5,000L 42 -30～250
Distillation Towers SUS, GL 1,000～2,000L 2 －
Centrifugal separator SUS, Fresin Coating 20～48inch 8 －
Dryer SUS, GL 300～2,000L 4 －
Filter Dryer SUS 300～2,700L 8 －

<AGC Wakasa Chemicals: Kaminaka Plant> (Wakasa-cho, Mikata Kaminaka-gun, Fukui Prefecture)

AGC Wakasa Chemicals
Equipment Material Volume Numbers Design Temp. (°C)
Reactors Stainless (SUS), Glass Lining (GL),
Hastelloy, Others		 2,000～15,000L
（200～300L）		 64
（4）		 -45～280
Distillation Towers Hastelloy, SUS, GL 3,000～15,000L 11 ～280
Centrifugal separator Hastelloy, SUS, Fresin Coating 36～60inch
（33inch）		 13
（1）		 －
Dryer Hastelloy, SUS, GL 3,000～5,000L
（50L）		 9
（1）		 ～130

※Information on equipment for trial production is shown in (　)

Equipment compatible with relatively large quantities Equipment compatible with relatively large quantities

Special technology

AGC is a chemical company with world class organic synthesis technology, production technology and production equipment.
In particular, we have extensive experiences in manufacturing and handling halogen containing compounds; F, Cl, Br and I.
We have a prolific track record in halogenation, including fluorination, and ultra low temperature reactions, and meet the various needs of customers.

Halogenation

  • Halogenation reactions (F, Cl, Br, I)
  • Halogen exchange reaction
  • Synthesis of fluorine-containing heterocyclic compounds
  • Perfluoroalkyl group introduction
  • Fully equipped with corrosion-resistant equipment
  • Iodine recovery/recycling
  • etc.

Various organic synthesis technologies

  • Amidation reaction
  • Corey Tchaikovsky Reaction
  • Friedel-Crafts reaction
  • Grignard reaction
  • Various cross-coupling reactions
  • Carboxylation
  • Oxidation reaction
  • Reduction reaction (hydrogenation)
  • Reaction using high pressure gas (toxic/flammable high pressure gas)
  • High temperature reaction (~250℃ JKT)
  • Low temperature reaction (-50℃ ~ JKT)
  • Distillation (normal pressure distillation, vacuum distillation)
  • Thin film distillation
  • Flow reaction (under development)
  • Photoreaction (under development)
  • etc.

We will also respond to reactions other than those listed above, so please contact us.

Available fluorine-containing building blocks

Utilizing our own tetrafluoroethylene (TFE), chlorotrifluoroethylene (CTFE), and trifluoroacetic acid, we also support and provide the use of fluorine-containing building blocks (compounds with fluorine atoms).

Some example reactions

Examples of raw materials that can be used

No. CAS No. CHEMICAL NAME
1 76-05-1 Trifluoroacetic acid
2 407-25-0 Trifluoroacetic anhydride
3 383-63-1 Ethyl trifluoroacetate
4 2923-18-4 Sodium trifluoroacetate
5 354-38-1 Trifluoroacetamide
6 677-69-0 Heptafluoro-2-iodopropane
7 455-14-1 4-(trifluoromethyl)aniline
8 122665-97-8 4,4-difluorocyclohexane carboxylic acid
9 148043-73-6 4,4,5,5,5-Pentafluoro-1-pentanol
10 30071-93-3 3,5-Bis(trifluoromethyl)acetophenone
11 3862-73-5 2,3,4-Trifluoroaniline
12 328-93-8 2,5-Bis(trifluoromethyl)aniline
13 214557-89-8 3,5,7-trifluoroadamantane carboxylic acid
14 118612-00-3 N,N-Dimethylanilinium tetrakis-(pentafluorophenyl)borate
15 136040-19-2 Triphenylcarbenium tetrakis-(pentafluorophenyl) borate
16 75-29-6 2-chloropropane
17 557-98-2 2-chloropropene
18 542-75-6 1,3-dichloropropene
19 96-18-4 1,2,3-trichloropropane
20 142-28-9 1,3-dichloropropane
21 96-24-2 3-chloro-1,2-propanediol
22 96-23-1 1,3-dichloro-2-propanol
23 627-30-5 3-chloro-1-propanol
24 616-30-8 3-amino-1,2-propanediol
25 107-11-9 3-amino-1-propene
26 124-02-7 diallylamine
27 102-70-5 triallylamine
28 870787-05-6 methyl 3-(trifluoromethyl)pyrazine-2-carboxylate
29 873056-62-3 3',4'-difluorobiphenyl-2-amine
The PERFECT derivative list
The difluoro acetic acid derivative list

Environmental measures

We have activated sludge wastewater treatment equipment, HF-containing exhaust gas treatment equipment, and fluorine-containing organic post-compound combustion equipment.