AGC offers contract manufacturing services for agrochemical intermediates and active ingredients matched to customers’ needs using precision organic synthesis technology.
With our efficient process development, we supply intermediates and active ingredients on an industrial scale.

Service overview

AGC offers custom development and manufacturing services for agrochemicals intermediates and active ingredients (AI) with our expertise in organic chemistry.
AGC offers the continued cost reductions through more efficient manufacturing process improvement and the solutions for the challenges in manufacturing process with alternative synthetic routes.
AGC has established a reliable and resilient supply by having the multi-functional production facilities, and the stable raw material procurements with unique supply chain scheme.

Our Uniqueness

  • Stable production by risk diversification
    AGC has established a reliable and resilient supply by having the multi-functional production facilities, the stable raw material procurements with unique supply chain scheme.
  • One stop solution from process development to manufacturing
    AGC offers custom development and manufacturing services for agrochemicals from intermediates to active ingredients (AI) with our expertise in organic chemistry.
    And AGC offers the continued cost reductions through efficient manufacturing process improvement and the solutions for the challenges in the manufacturing process with alternative synthetic routes.
  • Global standard high quality and stable management system
    AGC has obtained EcoVadis Gold rating (top 5%).
    Under the integrated quality management system with our pharmaceutical quality assurance system, provides the high quality and stable quality service.

Manufacturing bases / equipment

<AGC Wakasa Chemicals: Kaminaka Plant> (Wakasa-cho, Mikata Kaminaka-gun, Fukui Prefecture)

AGC Wakasa Chemicals
  • Intermediates and active ingredients
  • Agrochemical CDMO
Equipment Material Volume Numbers Design Temp. (°C)
Reactors Stainless (SUS), Glass Lining (GL),
Hastelloy, Others		 2,000～15,000L
（200～300L）		 64
（4）		 -45～280
Distillation Towers Hastelloy, SUS, GL 3,000～15,000L 11 ～280
Centrifugal separators Hastelloy, SUS, Fresin Coating 36～60inch
（33inch）		 13
（1）		 －
Dryer Hastelloy, SUS, GL 3,000～5,000L
（50L）		 9
（1）		 ～130

※Information on equipment for trial production is shown in (　)

We have equipment to meet the increasing demand for agrochemical intermediates and active ingredients. We have equipment to meet the increasing demand for agrochemical intermediates and active ingredients.

<AGC Wakasa Chemicals: Obama Plant / pharmaceuticals Plant > (Obama City, Fukui Prefecture)

AGC Wakasa Chemicals
  • cGMP compliant
  • Starting materials and raw materials
Equipment Material Volume Numbers Design Temp. (°C)
Reactors Stainless (SUS), Glass Lining (GL),
PFA Lining		 100～5,000L 42 -30～250
Distillation Towers SUS, GL 1,000～2,000L 2 －
Centrifugal separator SUS, Fresin Coating 20～48inch 8 －
Dryer SUS, GL 300～2,000L 4 －
Filter Dryer SUS 300～2,700L 8 －
We are capable of synthesizing from 1 kg to 100 t of pharmaceutical / agrochemical intermediates and specialty chemical products. We are capable of synthesizing from 1 kg to 100 t of pharmaceutical / agrochemical intermediates and specialty chemical products.
We have equipment capable of manufacturing active pharmaceutical ingredients. We have equipment capable of manufacturing active pharmaceutical ingredients.

Special technology

AGC is a chemical company with world class organic synthesis technology, production technology and production equipment.
In particular, we have extensive experiences in manufacturing and handling halogen containing compounds; F, Cl, Br and I.
We have a prolific track record in halogenation, including fluorination, and ultra low temperature reactions, and meet the various needs of customers.

Halogenation

  • Halogenation reactions (F, Cl, Br, I)
  • Halogen exchange reaction
  • Synthesis of fluorine-containing heterocyclic compounds
  • Perfluoroalkyl group introduction
  • Fully equipped with corrosion-resistant equipment
  • Iodine recovery/recycling
  • etc.

Various organic synthesis technologies

  • Amidation reaction
  • Corey Tchaikovsky Reaction
  • Friedel-Crafts reaction
  • Grignard reaction
  • Various cross-coupling reactions
  • Carboxylation
  • Oxidation reaction
  • Reduction reaction (hydrogenation)
  • Reaction using high pressure gas (toxic/flammable high pressure gas)
  • High temperature reaction (~250℃ JKT)
  • Low temperature reaction (-50℃ ~ JKT)
  • Distillation (normal pressure distillation, vacuum distillation)
  • Thin film distillation
  • Flow reaction (under development)
  • Photoreaction (under development)
  • etc.

We will also respond to reactions other than those listed above, so please contact us.

Available fluorine-containing building blocks

Utilizing our own tetrafluoroethylene (TFE), chlorotrifluoroethylene (CTFE), and trifluoroacetic acid, we also support and provide the use of fluorine-containing building blocks (compounds with fluorine atoms).

Some example reactions

Examples of raw materials that can be used

No. CAS No. CHEMICAL NAME
1 76-05-1 Trifluoroacetic acid
2 407-25-0 Trifluoroacetic anhydride
3 383-63-1 Ethyl trifluoroacetate
4 2923-18-4 Sodium trifluoroacetate
5 354-38-1 Trifluoroacetamide
6 677-69-0 Heptafluoro-2-iodopropane
7 455-14-1 4-(trifluoromethyl)aniline
8 122665-97-8 4,4-difluorocyclohexane carboxylic acid
9 148043-73-6 4,4,5,5,5-Pentafluoro-1-pentanol
10 30071-93-3 3,5-Bis(trifluoromethyl)acetophenone
11 3862-73-5 2,3,4-Trifluoroaniline
12 328-93-8 2,5-Bis(trifluoromethyl)aniline
13 214557-89-8 3,5,7-trifluoroadamantane carboxylic acid
14 118612-00-3 N,N-Dimethylanilinium tetrakis-(pentafluorophenyl)borate
15 136040-19-2 Triphenylcarbenium tetrakis-(pentafluorophenyl) borate
16 75-29-6 2-chloropropane
17 557-98-2 2-chloropropene
18 542-75-6 1,3-dichloropropene
19 96-18-4 1,2,3-trichloropropane
20 142-28-9 1,3-dichloropropane
21 96-24-2 3-chloro-1,2-propanediol
22 96-23-1 1,3-dichloro-2-propanol
23 627-30-5 3-chloro-1-propanol
24 616-30-8 3-amino-1,2-propanediol
25 107-11-9 3-amino-1-propene
26 124-02-7 diallylamine
27 102-70-5 triallylamine
The PERFECT derivative list
The difluoro acetic acid derivative list

Environmental measures

We have activated sludge wastewater treatment equipment, HF-containing exhaust gas treatment equipment, and fluorine-containing organic post-compound combustion equipment.